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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Adv Drug Deliv Rev. 2021 Jul 30;178:113906. doi: 10.1016/j.addr.2021.113906

Figure 7.

Figure 7.

Approaches of UMGT for cancer immunotherapy. A) Transfection with plasmids and ultrasound. The ultrasound parameters were optimized to administer an immune gene construct in murine fibrosarcoma tumor models [159]. Copyright (2010) Elsevier; B) Transfection mediated by MB oscillation. Low frequency ultrasound was applied with the mixture of IFN-β plasmids and targeted MBs, and the immune cells were recruited at both sites of treated and distant tumors [21]. Copyright (2020) National Academy of Sciences; C) Transfection by ultrasound-sensitive delivery system. The mannose-modified lipoplexes were developed as ultrasound-responsive and APC-selective carriers for tumor antigen gene delivery. Reprinted with permission from [166]. Copyright (2011) American Chemical Society; D) Modulation of immune cells using UMGT. TriMix mRNA-loaded MBs were used to transfect DCs by sonoporation to activate T cells [170] Copyright (2014) Elsevier.