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. 2021 Oct 29;11:21304. doi: 10.1038/s41598-021-00706-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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EAC PDOs serve as avatars for patients’ responses to therapy. Relative PDO density in response to components of standard of care and alternative treatments. 2-way ANOVA parameters: P_i = significance of interaction (differential responses of organoid lines), P_c = significance of concentration/dose, P_o = significance of organoid line. Error bars = SEM, *P < 0.05, ΔP < 0.005, #P < 0.0005.