. Author manuscript; available in PMC: 2022 Nov 1.

Published in final edited form as: Adv Drug Deliv Rev. 2021 Aug 8;178:113918. doi: 10.1016/j.addr.2021.113918

Table 2:

Common miRNAs dysregulated in diabetes and LC

miRNA	Role in diabetes	References	Role in LC	References
miR-20b-5p	Elevated expression of miR-20b-5p in T2DM modulates insulin-stimulated glucose metabolism via AKT signaling.	[271]	Biomarker for NSCLC, overexpression of miR-20b promote NSCLC cell proliferation and migration	[272]
miR-20b-5p	Knock out of miR-20b-5p enhances diabetes associated wound healing and promotes wound angiogenesis	[259]		[273]
miR-126	Loss of endothelial miR-126 impairs peripheral angiogenic signaling in patients with DM	[274]	Downregulation of miR-126 in LC. Ectopic expression of miR-126 suppresses EMT and metastasis of LC cells, biomarker for NSCLC	[275]
miR-126	Downregulation of miR-126 regulates angiogenesis and vascular integrity, therapeutic agent for DM	[276]		[277]
miR-150	Higher expression of miR-150, miR-30a-5p seen in T2DM, predictors of T2DM and prediabetes	[278]	miR-150 overexpressed in LC. Knockdown of miR-150 inhibit LC cell viability	[279]
miR-30a-5p		[278]	miR-30a-5p downregulated in LC and p53/miR-30a-5p/SOX4 feedback loop mediates cellular proliferation, migration of NSCLC cells	[280] [281]
miR-194	Modulator of glucose metabolism, decreased expression in T2DM	[282]	Downregulated in HG condition, introduction of miR-194 suppressed the proliferation, migration, and invasion of LC cells induced by HG and suppresses metastasis of LC cells	[64] [283]
miR-27b	Negative regulator of hepatic gluconeogenesis, decreased in T2DM conditions	[284]	miR-27b expression downregulated in LC. Overexpression of miR-27b further suppresses EMT in LC	[285]
miR-375	Increased expression in STZ treated mice, marker of β-cell death and potential predictor of diabetes.	[286]	Upregulation of miR-375 predicts chemoresistance induction in SCLC	[287]
miR-214-3p	Decreased expression in T2DM, correlates with serum insulin and HbA1c level	[288]	Downregulation of miR-214-3p in LC negatively correlates with FGFR1 in LC patients. Overexpression of miR-214-3p inhibits EMT and Wnt/MAPK/AKT pathway	[289]
miR-let-7f-5p		[288]	Decreased expression of miR-let-7f-5p in plasma exosomes of NSCLC patients	[290]
miR-103	Decreased expression reported in prediabetes and diabetes rats	[291]	Reduced miR-103 expression negatively correlating with tumor grade seen in NSCLC tissues and cells	[292]