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. 2021 Oct 29;11:21308. doi: 10.1038/s41598-021-00830-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The count of splenocytes from mice vaccinated with saRNA LNPs, transfected Lactobacillus plantarum LNPs, and transfected Lactobacillus plantarum alone when re-stimulated with SARS-CoV-2 peptides by IFN-γ ELISpots (a). The secretion of IL-6 (b) by re-stimulated splenocytes. * indicates significance difference with P < 0.05 using one-way ANOVA with n = 10 biologically independent mice. All data were shown as mean ± SD.