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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Adv Drug Deliv Rev. 2021 Sep 13;178:113971. doi: 10.1016/j.addr.2021.113971

Table 2.

Commonly used natural polymers for the development of local delivery strategies to restore immune homeostasis from inflammation.

Polymer Structure Local Delivery Strategies Ref(s)
Polysaccharides
 Alginate graphic file with name nihms-1742581-t0011.jpg Alginate hydrogel; alginate/GelMA hydrogel; alginate capsules; alginate/PEI hydrogel; alginate MPs; alginate scaffold [41,89–99]
 Chitosan graphic file with name nihms-1742581-t0012.jpg Chitosan/pNIPAm/hyaluronic acid hydrogels; alginate-MPs/chitosan hydrogels [57,76,86, 92]
 Hyaluronic acid graphic file with name nihms-1742581-t0013.jpg Hyaluronic acid hydrogel; hyaluronic acid/tyramine hydrogel; hyaluronic acid/collagen hydrogel [34,36,104]
 Agarose graphic file with name nihms-1742581-t0014.jpg Agarose hydrogel; lipid microtubes/agarose hydrogel; gelatin-MPs/agarose scaffold [108–110]
Protein-based polymers
 Collagen graphic file with name nihms-1742581-t0015.jpg Collagen scaffolds; hyaluronic acid/collagen hydrogels [58,88,112]
 Silk fibroin graphic file with name nihms-1742581-t0016.jpg Silk hydrogels [111,113,114]
 Gelatin graphic file with name nihms-1742581-t0017.jpg Gelatin hydrogels; gelatin-MPs/agarose scaffold [110,115–118]