. Author manuscript; available in PMC: 2022 Nov 1.

Published in final edited form as: Adv Drug Deliv Rev. 2021 Sep 13;178:113971. doi: 10.1016/j.addr.2021.113971

Table 6.

Local delivery strategies for antigen or antigen and small molecules/biologics used to restore immune homeostasis from inflammation.

Antigen-Specific Approach		Delivery Strategy	Disease Model	Ref(s)
Antigen
PLP		PLGA MPs	Multiple sclerosis	[240,241]
PLP		Collagen scaffold	Multiple sclerosis	[112]
Ins2_9–23		PLGA MPs	Inflammatory diabetes	[245]
Antigen and small molecules/biologics
MOG	Rapamycin	PLGA MPs	Multiple sclerosis	[43]
	Dexamethasone	Acetalated dextran MPs	Multiple sclerosis	[246]
	Vitamin D3, TGF-β1, GM-CSF	PLGA MPs	Multiple sclerosis	[185]
Insulin B	Vitamin D3, TGF-β1, GM-CSF	PLGA MPs	Inflammatory diabetes	[187]
Denatured insulin	Vitamin D3, TGF-β1, GM-CSF	PLGA MPs	Inflammatory diabetes	[188]
Collagen II	Vitamin D3, TGF-β1, GM-CSF	PLGA MPs	Inflammatory arthritis	[248]
Collagen II	PFK15 inhibitor	Poly-aKG MPs	Inflammatory arthritis	[152]