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Methods of RBC drug loading.
| Drug loading | Approaches | |
|---|---|---|
| Inner | Via pores induced by hypotonic swelling | Established |
| Using MPP | Exploratory | |
| Genetic modification of reticulocytes | In progress | |
| Surface | Chemical conjugation to surface proteins | Exploratory |
| Insertion into membrane phospholipids | As above | |
| Physical absorption | As above | |
| Binding mediated by affinity ligand | As above | |
| Membrane | ||
Abbreviations: MPP – membrane permeabilizing protein
