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. 2021 Oct 29;12(11):1027. doi: 10.1038/s41419-021-04307-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Endogenous Fe levels in the lungs of IIR-ALI mice, as evidenced by Fe assay. B Representative transmission electron micrographs of lung ultrastructure. Scale bars: 500 nm. C, D Evaluation and quantification of the GPX4, ferritin, and ferroportin protein expressions, under all conditions. E Evaluation of the lipid peroxide MDA levels under all conditions. F GSH levels under all conditions. G HE staining of the murine lung tissues after IIR and IIR + Fer-1. Scale bars: 200 μm. H The lung pathological damage score illustrating addition and decrease after Fer-1 administration, respectively. Data are expressed as mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001. Error bars denote standard error from three individual experiments.