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. 2021 Oct 29;12(11):1027. doi: 10.1038/s41419-021-04307-1

Fig. 6. Low TERT levels enhance ferroptosis, whereas TERT overexpression (OETERT) alleviates ferroptosis via upregulating SLC7A11.

Fig. 6

A Fe distribution and content. B, I Evaluation of cell viability after OGD/R, as evidenced by CCK8 assay. C, J MDA levels after OGD/R, as assessed by MDA assay. D, K GSH levels after OGD/R, as assessed by GSH assay. E, L Evaluation of ferritin and ferroportin (red), using immunohistochemistry. Nuclear staining done with DAPI (blue) after OGD/R. Scale bar: 100 μm. F, M Evaluation of Nrf2 and its potential downstream proteins via western blotting under different treatment conditions. G, N Protein quantification. H, O mRNA levels of the examined factors. Error bars denote standard error from three individual experiments. Data are expressed as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 denotes intergroup significant difference. *Relative to the sham control mice. #Relative to the OGD/R controls.