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. 2021 Oct 29;6:71. doi: 10.1038/s41536-021-00182-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Forest plots show mean effect size and 95% CI of genetically modified MSCs, matrix-embedded MSCs, and MSC derivatives for neurologic assessment (a), cognitive function at 4–5 weeks (b), and contusion volume at 4–5 weeks (c). Dots represent the single studies, and diamonds pooled data. Vertical pale gray bars indicate the mean and 95% CI of the pooled estimated effect size of the single modifications and vertical dotted bars represent 95% CI of the naïve + labeled MSC group.