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. 2021 Oct 29;7:324. doi: 10.1038/s41420-021-00719-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Schematic of the design of mild and severe AKI mice model. The mild and severe AKI were induced by 15 and 25 min of renal ischemic durations, respectively. Short- and long-term outcomes were evaluated in 2 and 28 days after surgery. b Serum creatinine and c blood urine nitrogen levels of two group mice subjected to mild and severe renal IRI at indicated time points. n = 5 for mild AKI and severe AKI mice, respectively. d Representative images of the renal cortex 2 days after surgery stained with HE. e Semi-quantitative scoring of renal tubular damage in kidneys at 48 h after surgery considering tubular dilation, brush border loss, tubular degeneration, tubular cast formation, and tubular necrosis. f Representative images of the renal cortex 28 days after surgery stained with HE. Asterisk represents the renal maladaptive-repaired tubules. g Semi-quantitative scoring of renal maladaptive repair in 28 days after surgery considering tubular atrophy, brush border loss, tubular degeneration, interstitial fibrosis. n = 3 mice for the sham group, n = 5 for mild and severe AKI per time-point group, respectively. Data are mean ± SD. ***P < 0.001, ****P < 0.0001. ns not significant. d, f Bar = 50 mm.