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. 2021 Oct 29;7:320. doi: 10.1038/s41420-021-00718-3

Fig. 2. Cholesterol depletion increases the mRNA levels of multiple autophagy-related genes.

Fig. 2

RNA-seq of Mv1Lu cells was as in Fig. 1. A Heat map of differentially expressed genes related to autophagy. Only those genes with significant differential expression (FDR < 0.05) are shown. B–D Box plot of three specific autophagy-related genes whose expression was significantly enhanced by CD: SQSTM1, which encodes p62 (B), MAP1LC3, encoding LC3 (C), and GABARAPL2, which encodes GEF-2 (D). The fold change (FC) and FDR-adjusted P-values are indicated.