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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Mol Psychiatry. 2021 Apr 30;27(5):2563–2579. doi: 10.1038/s41380-021-01110-4

Figure 3. Inhibition of IL-1β receptors in the brain increased aggressive behavior of male mice.

Figure 3.

a Schematic timeline of i.c.v. IL-1RA injection experiment. RI test: resident-intruder test. b-c Effect of i.v.c. IL-1RA injection on the attack latency (b) and duration of aggressive behaviors (c). d-e Detailed behavioral analysis for aggressive behaviors (d) and non-aggressive behaviors (e). Average data of first 2 days of resident intruder test was presented. f Schematic timeline of intra-DRN IL-1RA injection experiment. g-h Effect of intra-DRN IL-1RA injection on the attack latency (g) and duration of aggressive behaviors (h). i-j Detailed behavioral analysis for aggressive behaviors (i) and non-aggressive behaviors (j). Average data of 2-day resident intruder test was presented. Numbers in the parenthesis indicate the number of animals used in each group. +p<.10, *p<0.05, **p<0.01.