Fig. 2.

Enzyme catalyzed sterol biosynthetic pathway reactions leading to the formation of ergosterol and cholesterol in Leishmania and human, respectively. Enzymes required in each step of the reaction comprised HMGS, 3-Hydroxy-3-methyl-glutaryl-coenzyme A synthase; HMGR, 3-Hydroxy-3-methyl-glutaryl-coenzyme A reductase; FPPS, Farnesyl-pyrophosphate synthase; SQS, Squalene synthase; SQE, Squalene epoxidase; LSO, Lanosterol oxidase; CYP51, Sterol 14alpha-demethylase Cytochrome P450; 24-SMT, Δ²⁴ Sterol methyltransferase; 24-SR, Sterol C-24 reductase; Emopamil-Binding Protein (EBP), Sterol Δ⁸⁽⁷⁾ – isomerase; SC5DL, Sterol C-5 desaturase; and DHCR7, Sterol- Δ⁷-reductase