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. 2021 Apr 24;45(4):1152–1171. doi: 10.1007/s12639-021-01390-1

Table 1.

Validated pathways comprising plausible targets essential for parasite survival that are necessary for drug design against Leishmania parasites

Category Pathway/Enzyme References
Glycolysis Glycolytic pathway and glyoxalase enzymes Silva et al. (2005) and Padmanabhan et al. (2005)
Isoprenoid and sterol synthesis Squalene synthase, sterol 14α-demethylase Kumar Saha et al. (1986) and Pomel et al. (2015)
Folate metabolism Thymidylate synthase, dihydrofolate reductase and pteridine reductase Nare et al. (1997)
Polyamine metabolism Hypusine pathway, arginase, and ornithine decarboxylase Jiang et al. (1999)
Antioxidant metabolism and Detoxification Thiol pathway, superoxide dismutase and Thyperdoxin peroxidase Leroux and Krauth-Siegel (2016)
Nucleotide metabolism Purine salvage, nucleotide transporters Jain and Jain 2018)
Cell division and DNA replication Peptidase, topoisomerase, kinases Merritt et al. (2014) and Brumlik et al. (2011)