. 2021 Oct 2;7(4):1162–1172. doi: 10.1016/j.aninu.2021.09.003

Table 7.

Effects of pyridoxine on gene expression of signal pathway of dermal papilla cells (DPC)¹.

Gene	Pyridoxine concentration, μmol/L						RMSE	P-value
Gene	0	10	20	40	80	160	RMSE	P-value
PI3K/Akt signal pathway
Inppl1	1.00^c	3.46^a	3.55^a	2.93^ab	1.54^bc	1.60^bc	1.361	0.001
Inpp4b	1.00^b	3.91^a	2.24^ab	1.31^b	1.94^b	1.20^b	1.732	0.018
Frk	1.00	0.80	0.98	0.71	1.14	0.79	0.382	0.231
Phlda3	1.00^c	1.68^b	1.87^ab	1.67^b	1.42^bc	2.27^a	0.503	<0.001
Wnt signal pathway
Wnt10b	1.00^b	1.12^b	1.51^ab	2.54^a	2.22^a	2.03^ab	0.957	0.012
CTNNB1	1.00^c	2.50^a	2.20^ab	2.60^a	1.29^bc	1.51^abc	1.073	0.017
GSK-3β	1.00	1.67	1.86	1.64	1.83	1.79	0.636	0.094
DKK1	1.00^a	0.51^b	0.52^b	0.16^c	0.51^b	0.47^b	0.453	0.002
Notch signal pathway
Notch1	1.00^c	2.82^ab	2.75^ab	2.66^ab	1.66^bc	3.42^a	1.278	0.006
JAG1	1.00^b	3.17^a	3.26^a	2.60^a	2.66^a	3.08^a	0.860	<0.001
Hes1	1.00^c	1.12^bc	0.92^c	0.91^c	1.89^a	1.39^b	0.356	<0.001
Hes5	1.00^c	1.65^ab	1.75^ab	1.87^a	1.27^bc	1.26^bc	0.453	0.002
BMP signal pathway
BMP2	1.00	1.17	0.95	0.75	1.10	0.89	0.403	0.369
BMP4	1.00	0.90	1.15	0.84	1.22	1.06	0.465	0.585
TGF-β1	1.00	1.24	1.09	1.19	0.94	0.88	0.459	0.575

Inppl1 = inositol polyphosphate phosphatase like 1; Frk = fyn-related kinase; Phlda3 = pleckstrin homology like domain family A member 3; CTNNB1 = catenin beta 1; GSK-3β = glycogen synthase kinase 3 beta; DKK1 = dickkopf-1; JAG1 = Jagged1; BMP = bone morphogenetic protein; TGF-β1 = transforming growth factor-β.

^{a, b, c} Within a row, means with different superscript letters are significantly different (P < 0.05).

Data represent means and root mean error (RMSE), n = 8 for per group.