Table 2.
Incidence of Different Corneal Lesions at Different Time Points by IVCM Among the Rats of MCMV Group
| Day Postinfection | |||||||
|---|---|---|---|---|---|---|---|
| n/N (%) | |||||||
| Types of Corneal Lesions by IVCM | 0 | 1 | 2 | 3 | 7 | 14 | P Value* |
| “Black holes” | 0/8 (0%) | 4/8 (50%) | 2/8 (25%) | 3/8 (37.5%) | 2/8 (25%) | 2/8 (25%) | 0.386 |
| Enlarged intercellular gaps | 0/8 (0%) | 3/8 (37.5%) | 4/8 (50%) | 3/8 (37.5%) | 2/8 (25%) | 2/8 (25%) | 0.370 |
| Inflammatory cell infiltration | 0/8 (0%) | 1/8 (12.5%) | 2/8 (25%) | 4/8 (50%) | 6/8 (75%) | 2/8 (25%) | 0.019 |
| Hyper-reflective Kps | 0/8 (0%) | 7/8 (87.5%) | 7/8 (87.5%) | 5/8 (62.5%) | 7/8 (87.5%) | 3/8 (37.5%) | <0.001 |
| Bright nuclear cells | 0/8 (0%) | 1/8 (12.5%) | 3/8 (37.5%) | 3/8 (37.5%) | 4/8 (50%) | 2/8 (25%) | 0.274 |
| Blurred endothelial layer | 0/8 (0%) | 2/8 (25%) | 3/8 (37.5%) | 3/8 (37.5%) | 1/8 (12.5%) | 0/8 (0%) | 0.180 |
n = number of rats with different types of endothelial changes at different time points; N = 8, total number; P value* was the results of comparing number of rats with different endothelial changes at different dpi by Fisher s exact test; IVCM, in-vivo confocal microscopy.