Table 1.
Genotype/allele distribution of ACE2 SNPs in COVID‐19 patients according to the severity of the disease.
| SNP | Genotype/Allele | Severity |
χ2 | P value | |||
|---|---|---|---|---|---|---|---|
| Mild (%)(n = 2) | Common (%)(n = 184) | Severe (%)(n = 7) | Critical (%)(n = 3) | ||||
| rs4646142 | GG | 0 (0) | 60 (32.61) | 3 (42.86) | 1 (33.33) | 1.879 | 0.9305 |
| GC | 1 (50) | 48 (26.09) | 1 (14.29) | 1 (33.33) | |||
| CC | 1 (50) | 60 (32.61) | 3 (42.86) | 1 (33.33) | |||
| G | 1 (25) | 168 (50) | 7 (50) | 3 (50) | 0.9889 | 0.8039 | |
| C | 3 (75) | 168 (50) | 7 (50) | 3 (50) | |||
| rs20248683 | TT | 0 (0) | 1 (0.54) | 0 (0) | 0 (0) | 1.753 | 0.941 |
| GT | 0 (0) | 22 (11.96) | 0 (0) | 0 (0) | |||
| GG | 2 (100) | 156 (84.78) | 7 (100) | 3 (100) | |||
| T | 0 (0) | 24 (6.7) | 0 (0) | 0 (0) | 1.717 | 0.6332 | |
| G | 4 (100) | 334 (93.3) | 14 (100) | 6 (100) | |||
| rs4240157 | CC | 0 (0) | 6 (3.26) | 1 (14.29) | 0 (0) | 2.778 | 0.8362 |
| CT | 0 (0) | 4 (2.17) | 0 (0) | 0 (0) | |||
| TT | 2 (100) | 172 (93.48) | 6 (85.71) | 3 (100) | |||
| C | 0 (0) | 16 (4.4) | 2 (14.29) | 0 (0) | 3.480 | 0.3233 | |
| T | 4 (100) | 348 (95.6) | 12 (85.71) | 6 (100) | |||
| rs6632677 | GG | 1 (50) | 160 (86.96) | 5 (71.43) | 3 (100) | 14.23 | 0.0272* |
| GC | 0 (0) | 15 (8.15) | 0 (0) | 0 (0) | |||
| CC | 1 (50) | 9 (4.89) | 2 (28.57) | 0 (0) | |||
| G | 2 (50) | 335 (91.03) | 10 (71.43) | 6 (100) | 13.64 | 0.0034** | |
| C | 2 (50) | 33 (8.97) | 4 (28.57) | 0 (0) | |||
| rs2074192 | CC | 1 (50) | 78 (42.39) | 4 (57.14) | 1 (33.33) | 1.921 | 0.9268 |
| CT | 1 (50) | 45 (24.46) | 1 (14.29) | 1 (33.33) | |||
| TT | 0 (0) | 56 (30.43) | 2 (28.57) | 1 (33.33) | |||
| C | 3 (75) | 201 (56.15) | 9 (64.29) | 3 (50) | 1.024 | 0.7955 | |
| T | 1 (25) | 157 (43.85) | 5 (35.71) | 3 (50) | |||
P value is for Chi-square test.