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. Author manuscript; available in PMC: 2022 Oct 15.
Published in final edited form as: J Immunol. 2021 Sep 20;207(8):1959–1963. doi: 10.4049/jimmunol.2000986

Figure 4.

Figure 4.

Intestinal IL-17RA signaling mediates microbiota-dependent changes in glucose metabolism. A) RT-PCR evaluation of fecal SFB levels before (day 0) and after (day 105) HFD treatment. B) Family-level 16S rRNA sequencing data collected from fecal samples. C) Weight gain of Il17rafl/fl (n = 2) and Il17raΔIEC (n = 3) mice treated with an antibiotics mixture starting week 12 of HFD. D) GTT of Il17ra1fl/fl (n = 2) and Il17raΔIEC (n = 3) mice fed HFD for 16 wk and treated with an antibiotic mixture starting on week 12. E) Relative weight of eWAT after mice were fed HFD. F) H&E staining of liver tissues from HFD- and antibiotics-treated Il17rafl/fl (n = 2) and Il17raΔIEC (n = 3) mice. G) ORO staining (left) and quantification (right) of liver tissues from HFD- and antibiotics-treated Il17rafl/fl (n = 2) and Il17raΔIEC (n = 3) mice. Data from A and B are obtained from two separate experiments. For graph A, error bars depict the mean ± SEM. For graphs C, D, E, and G (right), error bars depict the mean ± SD. **p < 0.01, Mann Whitney U test and two-tailed, two-way ANOVA.