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. 2021 Oct 30;22:216. doi: 10.1186/s12875-021-01561-2

Table 3.

Products advised by the pharmacists for a selected clinical symptoms of common cold

Symptom Patients receiving medications [n] Statistics
headache paracetamol [329] p > 0.05
acetylsalicylic acid [41]
magnesium metamizole [15]
inosines [140]
homeopathics [17]
herbal products [5]
pseudoephedrine [67]
alpha-mimetics [150]
anti-histamines [27]
mucolytics [78]
sore throat products [53]
fever paracetamol [127] for paracetamol with ascorbate acid and pheniramine maleate OR = 2.105, 95%CI 1.152–3.843; p = 0.022
acetylsalicylic acid [25] for acetylsalicylic acid OR = 3.901, 95%CI 1.445–10.463; p = 0.009; for acetylsalicylic acid with phenylephrine HCL and chlorphenamine OR = 3.758, 95%CI 1.172–12.045; p = 0.04
magnesium metamizole [14] for magnesium metamizole OR = 2.983, 95%CI 1.365–6.52; p = 0.008
inosines [68] for inosines OR = 4.754, 95%CI 1.832–12.34; p = 0.001
homeopathics [14] p > 0.05
herbal products [8]
pseudoephedrine [17]
alpha-mimetics [54]
anti-histamines [7]
mucolytics [49] for ambroxol HCL OR = 2.664, 95%CI 1.353–5.242; p = 0.006
sore throat products [46] for choline salicylate OR = 3.017, 95%CI 1.199–7.591, p = 0.028; for chlorchinaldol OR = 3.222, 95%CI 1.491–6.96, p = 0.004; for amylmetacresol with levomenthol and 2,4-dichlorobenzol OR = 3.677, 95%CI 1.515–8.933, p = 0.005
rhonorrhea paracetamol [265] for paracetamol with phenylephrine HCL OR = 8.036, 95%CI 3.154–20.477, p < 0.001
acetylsalicylic acid [28] p > 0.05
magnesium metamizole [4]
inosines [90] for inosines OR = 10.509, 95%CI 4.153–26.591, p < 0.001
homeopathics [13] p > 0.05
herbal products [5]
pseudoephedrine [72]
alpha-mimetics [166] for xylometazoline in nasal spray OR = 8.96, 95%CI 2.726–29.452, p < 0.001; for xylometazoline gel form OR = 4.366, 95%CI 2.508–7.603, p < 0.001
anti-histamines [28] for fexofenadine HCL OR = 4.987, 95%CI 1.446–16.95, p = 0.009
mucolytics [52] p > 0.05
sore throat products [41]
cough paracetamol [185] for paracetamol, ascorbic acid and phenylephrine HCL OR = 5.667, 95%CI 1.132–28.378, p = 0.046; for paracetamol, ascorbic acid and pheniramine maleate OR = 2.261, 95% CI 1.242–4.092, p = 0.01; for paracetamol, ascorbic acid and phenylephrine HCL OR = 4.515, 95%CI 1.821–11.196, p < 0.001; for paracetamol, phenylephrine HCL and ascorbic acid (in a form of tablets) OR = 2.771, 95%CI 1.292–5.945, p = 0.012
acetylsalicylic acid [27] p > 0.05
magnesium metamizole [7]
inosines [81] for inosines OR = 1.812, 95%CI1.175–2.794, p = 0.009
homeopathics [15] p > 0.05
herbal products [3]
pseudoephedrine [14]
alpha-mimetics [53]
anti-histamines [14]
mucolytics [105] for bromohexide HCL OR = 18.391, 95%CI 6.396–52.877, p < 0.001; of ambroxol HCL OR = 9.57, 95%CI 3.869–23.671, p < 0.001; of acetylcysteine OR = 8.527, 95%CI 2.822–25.759, p < 0.001
sore throat products [47] for chlorchinaldol OR = 4.222, 95%CI 1.867–9.546, p < 0.001
fatigue paracetamol [169] for paracetamol with ascorbic acid and phenylephrine HCL OR = 3.378, 95%CI 1.431–7.979, p = 0.007; for paracetamol with phenylephrine HCL and ascorbic acid (in form of tablets) OR = 2.307, 95%CI 1.086–4.902, p = 0.043; for paracetamol with pseudoephedrine and dextromethorphan OR = 1.917, 95%CI 1.131–3.252, p = 0.021
acetylsalicylic acid [26] for acetylsalicylic acid with pseudoephedrine OR = 3.831, 95%CI 1.263–11.62, p = 0.024; for acetylsalicylic acid with ascorbic acid OR = 3.041, 95% CI 1.136–8.141, p = 0.04
magnesium metamizole [5] p > 0.05
inosines [73] for inosines OR = 1.715, 95%CI 1.107–2.657, p = 0.021
homeopathics [12] p > 0.05
herbal products [2]
pseudoephedrine [10]
alpha-mimetics [44]
anti-histamines [8]
mucolytics [50]
sore throat products [49] for choline salicylate OR = 4.718, 95%CI 1.76–12.65, p = 0.002; for amylmetacresol with levomenthol and 2,4-dichlorobenzol OR = 3.517, 95%CI 1.428–8.664, p = 0.008