Fig. 1.

Effect of exercise on glucose tolerance and insulin sensitivity in HFD-fed mice. Male C57Bl/6J mice were subjected to treadmill exercise or no exercise during HFD feeding. After 4 weeks, the intraperitoneal glucose tolerance test (IPGTT) and insulin tolerance test (ITT) were utilized to evaluate glucose tolerance and insulin sensitivity, respectively. To depict significant changes between groups, the area under the curve (AUC) of IPGTT and ITT was calculated by the trapezoid method. A IPGTT curve. B the AUC of IPGTT. C ITT curve. D the AUC of ITT. Values are mean ± SD. n = 8 each group, * p < 0.05