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. 2021 Oct 30;9:175. doi: 10.1186/s40478-021-01276-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Longitudinal trajectories of RT-QuIC seeding profiles. Out of the 100 PD patients included in this longitudinal analysis, 86 were RT-QuIC seeding positive while 14 did not show seeding. A Linear mixed model analysis in the longitudinal PD cohort with repeated lumbar puncture and RT-QuIC assay measurements revealed that time had no significant impact on the number of positive RT-QuIC seeding replicates over the course of the disease, neither in those patients who were seeding positive nor in those who were seeding negative (p = 0.670). B, C Similarly, RT-QuIC seeding positives showed stable results of Imax (p = 0.558) and LAG phase (p = 0.324) over time