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IGF-1 protein delivery for cartilage repair. Cationized gelation nanoparticles, PEGylated dendrimers IGF-1, PLGA, and fusion protein of IGF-1 with the HB domain of heparin-binding epidermal growth factor-like growth factor or scFv-Fc were used to target delivery of IGF-1 to reduce cartilage degeneration. Conjugating IGF-1 protein into the scaffolds can penetrate into thick cartilage
