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. 2021 Oct 30;21:1165. doi: 10.1186/s12885-021-08827-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Correlation analysis of the 25-lncRNA risk signature with HCC early recurrence in the validation and entire TCGA cohort. A) The 149 HCC patients in the validation cohort were ranked according to their risk scores from low to high, and divided into the low-risk group (n = 69) and the high-risk group (n = 80) by using the same risk score cut-off in the training cohort; B) The 25-lncRNA expression profile in the 149 HCC patients. The 19 risk lncRNAs were enriched in the high-risk group and the 6 protective lncRNAs were enriched in the low-risk group; C) 69.09% and 63.01% HCC patients with recurrence in 1-year and 2-year respectively were classified in the high-risk group, and 30.91% and 36.99% HCC patients with recurrence in 1-year and 2-year respectively were assigned in the low-risk group (P = 0.024); D) The 299 HCC patients in the entire TCGA cohort were ranked according to their risk scores from low to high, and divided into the low-risk group (n = 144) and the high-risk group (n = 155) by using the same risk score cut-off in the training cohort; E) The 25-lncRNA expression profile in the 299 HCC patients. The 19 risk lncRNAs were enriched in the high-risk group and the 6 protective lncRNAs were enriched in the low-risk group; F) 74.46% and 69.44% HCC patients with recurrence in 1-year and 2-year respectively were assigned in the high-risk group, and 25.24% and 30.56% HCC patients with recurrence in 1-year and 2-year respectively were assigned in the low-risk group (P = 0.0004); G and H) Correlation of risk score with 1-year (G) or 2-year DFS (H) in the recurrent HCC patients in the high-risk group of the entire TCGA cohort