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. 2021 Oct 30;14:145. doi: 10.1186/s13048-021-00883-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 15 — Effect of FSH treatment on alternatively spliced Fshr-1 and Fshr-3 transcripts by qRT-PCR under different experimental conditions. Various treatment groups showed higher upregulation of Fshr-3 compared to canonical Fshr-1, which was minimally regulated. Intact (PMSG 10 IU) (A) and chemoablated (rFSH 10 IU) (B) testis and total cells isolated from intact (C) and chemoablated (D) testis. Note > 100-fold increase in Fshr3 in cells in vitro from chemoablated testis. Sertoli cells also respond to FSH treatment, and both Fshr-1 (> 8 fold) and Fshr-3 (> 16 fold) transcripts are upregulated. SCA-1 sorted cells showed > 80 fold increase in Fshr3 compared to minimal increase in Fshr-1. Fshr-3 appears to be the more predominant transcript through which FSH exerts its action on the stem cells [52]