Fig. 1.

Microglia in the AP during the progression of CIA. A–L Representative images of immunostaining for Iba-1 in the AP during each disease phase in saline (A–B), FA (E–H), and CIA groups (I–L). Dashed lines indicate region of the AP. Boxed areas are shown at higher magnification on the right (a–x). Abbreviations: AP, area postrema; CIA, collagen-induced arthritis; FA, Freund’s adjuvant; Iba-1, ionized calcium-binding protein-1