Table 3.

Correlations between years of education and biomarkers of AD-related pathology: linear regression analysis

AD-related pathology biomarkers	Relationships with years of education
	HC			aMCI			CDR1 (mild dementia)			CDR2 (moderate dementia)			CDR3 (severe dementia)
	β (SE)	p	B	β (SE)	p	B	β (SE)	p	B	β (SE)	p	B	β (SE)	p	B
GMV of dACC	−0.001 (0.002)	0.7	−0.062	− 0.003 (0.002)	0.038 *	− 0.258	− 0.007 (0.002)	0.006**	− 0.753	− 0.006 (0.005)	0.233	− 0.569	−0.005 (0.004)	0.239	−0.568
ReHo of left aITC	0.008 (0.005)	0.108	0.261	−0.003 (0.003)	0.372	−0.127	−0.018 (0.004)	0.000***	−0.739	− 0.038 (0.012)	0.006**	−1.485	− 0.007 (0.005)	0.247	− 0.62
ReHo of left pITC	0.003 (0.006)	0.649	0.076	−0.008 (0.004)	0.037 *	−0.284	−0.025 (0.006)	0.002**	−0.831	− 0.003 (0.014)	0.829	− 0.101	−0.011 (0.01)	0.305	−0.586
left aITC rsFC
right angular gyrus	0.002 (0.01)	0.814	0.038	−0.004 (0.009)	0.662	−0.061	−0.034 (0.01)	0.004**	−0.72	− 0.041 (0.026)	0.127	− 0.899	−0.036 (0.012)	0.017 *	−1.043
left mid frontal cortex	0.013 (0.008)	0.098	0.271	0.002 (0.008)	0.763	0.039	−0.031 (0.008)	0.002**	−0.717	−0.035 (0.019)	0.081	−0.873	0.003 (0.011)	0.78	0.103
right superior frontal cortex	0.002 (0.009)	0.835	0.032	−0.002 (0.007)	0.786	−0.038	−0.029 (0.009)	0.007**	−0.658	− 0.05 (0.021)	0.029*	−1.244	0.013 (0.012)	0.317	0.372

Structural MR (GMV): Adjusted for age, sex, MMSE, and TIV

Resting-state fMRI (ReHo and rsFC): Adjusted for age, sex, MMSE, and head motion parameters

Abbreviations: AD Alzheimer’s disease; aMCI amnestic mild cognitive impairment; HC healthy control; CDR Clinical Dementia Rating; SE standard error; GMV gray matter volume; ReHo Regional Homogeneity; rsFC resting-state functional connectivity; dACC dorsal anterior cingulate cortex; aITC anterior part of inferior temporal cortex; pITC posterior part of inferior temporal cortex; MMSE Mini-Mental State Examination; TIV total intracranial volume

β stand for unstandardized coefficients, B stand for standardized coefficients (Beta)

P< 0.05*, P< 0.01**, P< 0.001***