Table 4.
Correlations between ROI-based neuroimaging variables and clinical cognitive function scores in AD group
Cognitive system | Episodic memory | Semantic memory | Working memory | |||
---|---|---|---|---|---|---|
r | p | r | p | r | p | |
aGMV of dACC | 0.334 | 0.015* | 0.453 | 0.001** | 0.205 | 0.141 |
bReHo of left aITC | 0.172 | 0.217 | 0.049 | 0.728 | 0.021 | 0.884 |
bReHo of left pITC | 0.391 | 0.004** | 0.2 | 0.151 | 0.102 | 0.466 |
Left aITC rsFCb | ||||||
right angular gyrus | 0.312 | 0.023* | 0.082 | 0.562 | 0.089 | 0.525 |
Left middle frontal cortex | 0.338 | 0.013* | 0.277 | 0.045* | 0.084 | 0.552 |
right superior frontal cortex | 0.108 | 0.44 | −0.035 | 0.805 | −0.128 | 0.36 |
The relationship between neuroimaging variables and clinical cognitive function scores were assessed by using Pearson correlation analysis
aAdjusted for age, sex, education, and TIV
bAdjusted for age, sex, education, and head motion parameters
P< 0.05*, P< 0.01**, P< 0.001***
Abbreviations: AD Alzheimer’s disease; GMV gray matter volume; ReHo Regional Homogeneity; rsFC resting-state functional connectivity; dACC dorsal anterior cingulate cortex; aITC anterior part of inferior temporal cortex; pITC posterior part of inferior temporal cortex; TIV total intracranial volume; ROI region of interest