Table 2.
Dihydrolycorine fails to exert protective effects in MI rats injected with Ad-Runx1.
| Group (n = 8) | Sham+Ad-EV | MI+Ad-EV | MI+Dihy+Ad-EV | MI+Dihy+Ad-Runx1 | MI+Ad-Runx1 | MI+Ad-sh Runx1 |
|---|---|---|---|---|---|---|
| LVEF (%) | 79.26 ± 2.13 | 50.36 ± 1.45 | 64.16 ± 2.64∗# | 51.32 ± 3.63∗# | 48.41 ± 2.61∗# | 65.37 ± 3.14∗# |
| LVFS% | 39.3 ± 1.4 | 21.5 ± 3.2 | 31.6 ± 2.3∗# | 21.9 ± 4.1∗ | 20.8 ± 3.8∗# | 31.9 ± 2.6∗# |
| LVESD (mm) | 2.4 ± 0.26 | 3.6 ± 0.41 | 2.9 ± 0.35∗# | 3.2 ± 0.12∗# | 3.8 ± 0.32∗# | 2.8 ± 0.38∗# |
| LVEDD (mm) | 3.7 ± 0.4 | 4.9 ± 0.4 | 4.0 ± 0.4∗# | 4.8 ± 0.2# | 5.1 ± 0.6∗# | 3.9 ± 0.3∗# |
| E/A ratio | 2.14 ± 0.36 | 1.48 ± 0.45 | 1.83 ± 0.48# | 1.46 ± 0.61∗# | 1.42 ± 0.21∗# | 1.86 ± 0.36∗ |
| HR (bmp) | 520 ± 8 | 480 ± 5 | 502 ± 5∗# | 478 ± 4∗# | 469 ± 9∗ | 506 ± 7∗# |
Values are mean ± SD, P < 0.05. The data are presented as means and SD. ∗P < 0.05 versus sham+Ad-EV; #P < 0.05 versus MI+Ad-EV. LVEDD: left ventricular end-diastolic dimension; LVESD: left ventricular end-systolic dimension; LVEF: left ventricular ejection fraction; LVFS: left ventricular systolic function; HR: heart rate.