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. 2021 Oct 23;2021:1208690. doi: 10.1155/2021/1208690

Figure 5.

Figure 5

High metabolic activity can lead to increased ROS levels and cell death in melanoma and other cancer cells. Conversely, effective antioxidant responses can result in cell growth and metastasis. From Harris, I., Brugge, J. “The Enemy of My Enemy Is My Friend”. Nature 2015 12 (11); 527 (7577): 170-1. doi:10.1038/nature15644, commentary to Piskounova E, Agathocleous M, Murphy MM, Hu Z, Huddlestun SE, Zhao Z, Leitch AM, Johnson TM, DeBerardinis RJ, Morrison SJ. “Oxidative Stress Inhibits Distant Metastasis by Human Melanoma Cells.” Nature. 2015 Nov 12; 527 (7577): 186-91. doi:10.1038/nature15726. Epub 2015 Oct 14.