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. 2021 Jun 5;23(12):2513–2525. doi: 10.1007/s12094-021-02652-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Schema of the interaction of immune cells in the breast cancer tumor microenvironment. CD4+ /CD8+ /CD20+ TILs directly kill the tumor cells. TILs are supported by TAM1s and suppress the tumor cells. In contrast, TAM2s exerts an immunosuppressive function via the inhibition of T cells and B cells, indicating tumorigenic roles. TILs tumor-infiltrating lymphocytes, TAM1s tumor-associated macrophages-1, TAM2s tumor-associated macrophages-2