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. 2021 Jun 5;23(12):2513–2525. doi: 10.1007/s12094-021-02652-3

Table 1.

Associations with clinicopathological parameters and TAMs versus TILs status

Clinicopathological parameter CD68/CD4 CD68/CD8 CD68/CD20
High/low High/high Low/high Low/low p value High/low High/high Low/high Low/low p value High/low High/high Low/high Low/low p value
Age at diagnosis (years) 0.462 0.571 0.618
 < 60 11 15 14 12 13 14 14 11 13 13 14 12
 ≥ 60 17 10 13 15 12 14 11 18 18 9 17 11
Tumor size (cm) 0.124 0.727 0.131
 ≤ 2 13 15 21 17 13 18 16 19 15 13 24 14
 > 2 15 10 6 10 12 10 9 10 16 9 7 9
Histological grade 0.082 0.089 0.224
 I, II 6 5 7 13 5 6 5 15 7 4 10 10
 III 22 20 20 14 16 26 16 18 24 18 21 13
Histology 0.080 0.020 0.498
 IBC-NST 19 19 21 18 17 21 20 19 20 18 21 18
 IBC-NST with medullary pattern 2 6 3 0 1 6 4 0 4 4 3 0
 Ca with apocrine differentiation 4 0 3 3 3 0 1 6 4 0 4 2
 Metaplastic carcinoma 2 0 0 4 3 1 0 2 2 0 2 2
 ILC 1 0 0 1 0 0 0 2 1 0 1 0
 IMP 0 0 0 1 1 0 0 0 0 0 0 1
Lymph node status 0.578 0.532 0.729
 Absent 13 15 18 19 9 19 14 23 17 11 21 16
 Present 11 6 7 6 8 9 6 7 9 8 8 5
 N/A 4 4 2 2 4 4 1 3 5 3 2 2
Mib-1 index 0.065 0.043 0.068
 < 20% 2 3 5 9 2 3 3 11 3 2 6 8
 ≥ 20% 26 22 22 18 19 29 18 22 28 20 25 15
Unstained TILs 0.198 0.022  < 0.001
 Low (≤ 30%) 17 9 15 17 16 12 9 21 22 4 10 22
 High (> 30%) 11 16 12 10 9 16 16 8 9 18 21 1

IBC-NST invasive breast carcinoma of no special type, Ca carcinoma, ILC invasive lobular carcinoma, IMP invasive micropapillary carcinoma, N/A not applicable, TILs tumor-infiltrating lymphocytes

χ2 test. Italic type indicates a statistically significant difference (p < 0.05)