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. 2021 Aug 26;190(1):53–67. doi: 10.1007/s10549-021-06354-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Changes in central energy metabolism associated with estrogen status. a Tricarboxylic acid cycle (TCA) pathway. b Heat map showing effects of estrogens on TCA metabolites in mammary glands. c Differences in isocitrate across groups. d Differences in α-ketoglutarate across groups. e Differences in succinate across groups. f Changes in malate across groups. g Changes in fumarate across groups. (p ≤ 0.05)