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. 2021 Aug 26;190(1):53–67. doi: 10.1007/s10549-021-06354-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Changes in bile acid metabolism associated with estrogen bioavailability. a Bile acid synthesis pathway. b Heat map showing effects of estrogens on bile acid metabolism in mammary glands. c Changes in primary bile acid glycocholate metabolism across groups. d Changes in secondary bile acid glycodeoxycholate metabolism across groups. e Changes in secondary bile acid glycochenodeoxycholate metabolism across groups. f Changes in taurocholate across groups. (p < 0.05). (GCA glycocholic acid, TCA taurocholic acid, GCDCA glycochenodeoxycholic acid, TCDCA taurochenodeoxycholic acid, DCA deoxycholic acid, LCA lithocholic acid, GDCA glycodeoxycholic acid, TDCA taurodeoxycholic acid, GLCA glycolithocholic acid, TLCA taurolithocholic acid, GUDCA glycoursodeoxycholic acid, TUDCA tauroursodeoxycholic acid)