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. 2021 Oct 30;12(11):1033. doi: 10.1038/s41419-021-04293-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A the representative images of immunochemistry staining for LPS staining in pancreatic cancer tissues. B the representative images of immunochemistry staining for LPS staining in PDAC adjacent normal tissues. The correlation between serum LPS and Zonulin in PDAC patients (C) or benign pancreatic neoplasm patients (D). The serum LPS (E) and zonulin level (F) in patients with PDAC or benign pancreatic neoplasm. G FITC conjugated dextran were used to measure intestinal leakage after DSS treatment. H mice serum LPS were measured after DSS treatment. I the typical image of HE and LPS staining in orthotopic PDAC tissue.