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. 2021 Oct 30;12(11):1033. doi: 10.1038/s41419-021-04293-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A the process of LPS and anti-PD-L1 therapy animal experiment. B subcutaneous tumor derived from PBS + IgG isotype group, LPS + IgG isotype group, PBS + anti-PD-L1 group, and LPS + anti-PD-L1 group at the end of the experiments (n = 6). Tumor growth curve (C) and tumor volume (D) of tumor derived from each group. E representative image of tunnel staining in each group to evaluate apoptotic cells. F apoptosis cell was calculated as tunnel⁺ cells/ visual filed. G apoptotic cancer cells in each group was evaluated by calculating the percentage of PI-positive cells in all GFP-positive cells (n = 4). Tumor infiltrated CD3⁺ (H) and CD8⁺ (I) T cells were stained by immunochemistry and analyzed as positive staining number per high visual field (HP). Peritumoral GzmB (J) and intratumoral GzmB (K) distribution were calculated as GzmB^p/percentage of the peritumoral area or GzmBⁱ/percentage of peritumoral area in a visual field, separately. *, **, *** and n.s. means statistically significant difference at p < 0.05, p < 0.01, p < 0.001 and no significant, respectively.