Comparison 3. Comparison: mifepristone+misoprostol, vaginal versus oral.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Induction to abortion interval	2	237	Mean Difference (IV, Fixed, 95% CI)	7.03 [‐0.13, 14.20]
1.1 Misoprostol, 200 mcg oral versus 200 mcg vaginal	1	98	Mean Difference (IV, Fixed, 95% CI)	13.0 [2.77, 23.23]
1.2 Misoprostol, 400 mcg oral versus 200 mcg vaginal	1	139	Mean Difference (IV, Fixed, 95% CI)	1.30 [‐8.73, 11.33]
2 Abortion within 24 hours	3	306	Odds Ratio (M‐H, Fixed, 95% CI)	0.53 [0.28, 1.02]
2.1 Misoprostol, 200 mcg oral versus 200 mcg vaginal	1	98	Odds Ratio (M‐H, Fixed, 95% CI)	0.26 [0.09, 0.78]
2.2 Misoprostol, 400 mcg oral versus 200 mcg vaginal	1	139	Odds Ratio (M‐H, Fixed, 95% CI)	0.83 [0.34, 2.01]
2.3 Misoprostol, 400 mcg oral versus 400 mcg vaginal	1	69	Odds Ratio (M‐H, Fixed, 95% CI)	0.97 [0.06, 16.17]
3 Surgical evacuation	2	208	Odds Ratio (M‐H, Fixed, 95% CI)	0.99 [0.48, 2.04]
3.1 Misoprostol, 400 mcg oral versus 200 mcg vaginal	1	139	Odds Ratio (M‐H, Fixed, 95% CI)	0.70 [0.31, 1.57]
3.2 Misoprostol, 400 mcg oral versus 400 mcg vaginal	1	69	Odds Ratio (M‐H, Fixed, 95% CI)	5.86 [0.65, 53.09]
4 Pain	2	208	Odds Ratio (M‐H, Fixed, 95% CI)	1.32 [0.66, 2.62]
4.1 Misoprostol, 400 mcg oral versus 200 mcg vaginal	1	139	Odds Ratio (M‐H, Fixed, 95% CI)	1.1 [0.43, 2.79]
4.2 Misoprostol, 400 mcg oral versus 400 mcg vaginal	1	69	Odds Ratio (M‐H, Fixed, 95% CI)	1.64 [0.59, 4.57]
5 Nausea	2	237	Odds Ratio (M‐H, Fixed, 95% CI)	1.02 [0.61, 1.70]
5.1 Misoprostol, 200 mcg oral versus 200 mcg vaginal	1	98	Odds Ratio (M‐H, Fixed, 95% CI)	0.64 [0.28, 1.47]
5.2 Misoprostol, 400 mcg oral versus 200 mcg vaginal	1	139	Odds Ratio (M‐H, Fixed, 95% CI)	1.37 [0.70, 2.68]
6 Vomiting	3	306	Odds Ratio (M‐H, Fixed, 95% CI)	0.98 [0.61, 1.56]
6.1 Misoprostol, 200 mcg oral versus 200 mcg vaginal	1	98	Odds Ratio (M‐H, Fixed, 95% CI)	0.64 [0.25, 1.63]
6.2 Misoprostol, 400 mcg oral versus 200 mcg vaginal	1	139	Odds Ratio (M‐H, Fixed, 95% CI)	1.10 [0.56, 2.15]
6.3 Misoprostol, 400 mcg oral versus 400 mcg vaginal	1	69	Odds Ratio (M‐H, Fixed, 95% CI)	1.21 [0.46, 3.17]
7 Diarrhoea	3	306	Odds Ratio (M‐H, Fixed, 95% CI)	1.95 [1.18, 3.22]
7.1 Misoprostol, 200 mcg oral versus 200 mcg vaginal	1	98	Odds Ratio (M‐H, Fixed, 95% CI)	2.15 [0.84, 5.50]
7.2 Misoprostol, 400 mcg oral versus 200 mcg vaginal	1	139	Odds Ratio (M‐H, Fixed, 95% CI)	2.21 [1.06, 4.61]
7.3 Misoprostol, 400 mcg oral versus 400 mcg vaginal	1	69	Odds Ratio (M‐H, Fixed, 95% CI)	1.36 [0.49, 3.77]