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. 2011 Jan 19;2011(1):CD005216. doi: 10.1002/14651858.CD005216.pub2

Comparison 15. Comparison: time interval misoprostol.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Induction to abortion interval 1 148 Mean Difference (IV, Fixed, 95% CI) ‐19.2 [‐36.02, ‐2.38]
2 Abortion within 24 hours 2 427 Odds Ratio (M‐H, Fixed, 95% CI) 1.50 [0.99, 2.26]
2.1 Misoprostol 400 mcg, every 3h versus every 6h 1 148 Odds Ratio (M‐H, Fixed, 95% CI) 1.74 [0.87, 3.48]
2.2 Misoprostol 600 mcg, every 6h versus every 12h 1 279 Odds Ratio (M‐H, Fixed, 95% CI) 1.38 [0.82, 2.31]
3 Blood loss (mL) 1 148 Mean Difference (IV, Fixed, 95% CI) ‐39.7 [‐83.12, 3.72]
4 Blood loss (>500 mL) 1 279 Odds Ratio (M‐H, Fixed, 95% CI) 1.33 [0.29, 6.07]
4.1 Misoprostol 600 mcg, every 6h versus every 12h 1 279 Odds Ratio (M‐H, Fixed, 95% CI) 1.33 [0.29, 6.07]
5 Surgical evacuation 1 155 Odds Ratio (M‐H, Fixed, 95% CI) 6.14 [0.31, 120.92]
5.1 Misoprostol 600 mcg, every 6h versus every 12h 1 155 Odds Ratio (M‐H, Fixed, 95% CI) 6.14 [0.31, 120.92]
6 Pain 2 427 Odds Ratio (M‐H, Fixed, 95% CI) 1.13 [0.75, 1.70]
6.1 Misoprostol 400 mcg, every 3h versus every 6h 1 148 Odds Ratio (M‐H, Fixed, 95% CI) 0.89 [0.45, 1.74]
6.2 Misoprostol 600 mcg, every 6h versus every 12h 1 279 Odds Ratio (M‐H, Fixed, 95% CI) 1.30 [0.78, 2.16]
7 Nausea 2 427 Odds Ratio (M‐H, Fixed, 95% CI) 1.26 [0.64, 2.45]
7.1 Misoprostol 400 mcg, every 3h versus every 6h 1 148 Odds Ratio (M‐H, Fixed, 95% CI) 0.75 [0.27, 2.15]
7.2 Misoprostol 600 mcg, every 6h versus every 12h 1 279 Odds Ratio (M‐H, Fixed, 95% CI) 1.82 [0.74, 4.49]
8 Vomiting 2 427 Odds Ratio (M‐H, Fixed, 95% CI) 1.47 [0.72, 3.00]
8.1 Misoprostol 400 mcg, every 3h versus every 6h 1 148 Odds Ratio (M‐H, Fixed, 95% CI) 1.0 [0.35, 2.82]
8.2 Misoprostol 600 mcg, every 6h versus every 12h 1 279 Odds Ratio (M‐H, Fixed, 95% CI) 2.08 [0.76, 5.70]
9 Diarrhoea 2 427 Odds Ratio (M‐H, Fixed, 95% CI) 1.28 [0.80, 2.04]
9.1 Misoprostol 400 mcg, every 3h versus every 6h 1 148 Odds Ratio (M‐H, Fixed, 95% CI) 2.06 [0.37, 11.59]
9.2 Misoprostol 600 mcg, every 6h versus every 12h 1 279 Odds Ratio (M‐H, Fixed, 95% CI) 1.23 [0.75, 2.00]