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. 2011 Jan 19;2011(1):CD005216. doi: 10.1002/14651858.CD005216.pub2

Comparison 20. Comparison: PGF2 versus hypertonic saline.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Induction to abortion interval 1 25 Mean Difference (IV, Fixed, 95% CI) ‐5.30 [‐6.67, ‐3.93]
1.1 20% NaCL versus single dose of 40 mg PGF 1 25 Mean Difference (IV, Fixed, 95% CI) ‐5.30 [‐6.67, ‐3.93]
2 Abortion within 24 hours 4   Odds Ratio (M‐H, Fixed, 95% CI) Subtotals only
2.1 20% NaCL versus single dose of 50 mg PGF 1 67 Odds Ratio (M‐H, Fixed, 95% CI) 1.52 [0.58, 3.98]
2.2 20% NaCl versus multiple doses of 25mg PGF 2 1579 Odds Ratio (M‐H, Fixed, 95% CI) 6.14 [4.91, 7.68]
2.3 20% NaCL versus single dose of 40 mg PGF 1 32 Odds Ratio (M‐H, Fixed, 95% CI) 15.78 [0.79, 314.27]
3 Blood loss >100 ml 3 165 Odds Ratio (M‐H, Fixed, 95% CI) 2.50 [0.79, 7.91]
3.1 20% NaCL versus single dose of 50 mg PGF 1 67 Odds Ratio (M‐H, Fixed, 95% CI) 8.30 [0.96, 71.72]
3.2 20% NaCL versus multuple doses of 25 mg PGF 1 66 Odds Ratio (M‐H, Fixed, 95% CI) 0.32 [0.01, 8.23]
3.3 20% NaCL versus single dose of 40 mg PGF 1 32 Odds Ratio (M‐H, Fixed, 95% CI) 1.62 [0.23, 11.26]
4 Blood loss >500 ml 1 1513 Odds Ratio (M‐H, Fixed, 95% CI) 3.05 [1.56, 5.97]
4.1 20% NaCL versus multiple doses of 25 mg PGF 1 1513 Odds Ratio (M‐H, Fixed, 95% CI) 3.05 [1.56, 5.97]
5 Nausea 1 1513 Odds Ratio (M‐H, Fixed, 95% CI) 3.01 [1.17, 7.72]
5.1 20% NaCL versus multiple doses of 25 mg PGF 1 1513 Odds Ratio (M‐H, Fixed, 95% CI) 3.01 [1.17, 7.72]
6 Vomiting 3 1646 Odds Ratio (M‐H, Fixed, 95% CI) 5.16 [4.12, 6.46]
6.1 20% NaCL versus single dose of 50 mg PGF 1 67 Odds Ratio (M‐H, Fixed, 95% CI) 22.4 [2.73, 183.71]
6.2 20% NaCL versus multiple doses of 25 mg PGF 2 1579 Odds Ratio (M‐H, Fixed, 95% CI) 5.01 [3.99, 6.28]
7 Diarrhoea 3 1646 Odds Ratio (M‐H, Fixed, 95% CI) 10.83 [6.17, 19.02]
7.1 20% NaCL versus single dose of 50 mg PGF 1 67 Odds Ratio (M‐H, Fixed, 95% CI) 2.07 [0.35, 12.13]
7.2 20% NaCL versus multiple doses of 25 mg PGF 2 1579 Odds Ratio (M‐H, Fixed, 95% CI) 12.47 [6.81, 22.82]
8 Surgical evacuation 3 1646 Odds Ratio (M‐H, Fixed, 95% CI) 1.60 [1.30, 1.96]
8.1 20% NaCL versus single dose of 50 mg PGF 1 67 Odds Ratio (M‐H, Fixed, 95% CI) 7.89 [2.01, 30.95]
8.2 20% NaCL versus multiple doses of 25 mg PGF 2 1579 Odds Ratio (M‐H, Fixed, 95% CI) 1.52 [1.24, 1.87]