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. 2011 Jan 19;2011(1):CD005216. doi: 10.1002/14651858.CD005216.pub2

Comparison 21. Comparison: combined regimen PGF2+hypertonic saline.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Induction to abortion interval 4 770 Mean Difference (IV, Fixed, 95% CI) ‐1.55 [‐3.53, 0.44]
1.1 100 ml 5% NaCl versus 100 ml 10% NaCl combined with PGF 2 230 Mean Difference (IV, Fixed, 95% CI) 2.21 [‐1.59, 6.00]
1.2 25 ml 20% NaCl versus 100 ml 10% NaCl combined with PGF 2 540 Mean Difference (IV, Fixed, 95% CI) ‐2.96 [‐5.29, ‐0.64]
2 Abortion within 24 hours 4 770 Odds Ratio (M‐H, Fixed, 95% CI) 1.33 [0.90, 1.97]
2.1 100 ml 5% NaCl versus 100 ml 10% NaCl combined with PGF 2 230 Odds Ratio (M‐H, Fixed, 95% CI) 0.69 [0.38, 1.26]
2.2 25 ml 20% NaCl versus 100 ml 10% NaCl combined with PGF 2 540 Odds Ratio (M‐H, Fixed, 95% CI) 2.30 [1.38, 3.86]
3 Blood loss (>500 ml) 4 770 Odds Ratio (M‐H, Fixed, 95% CI) 1.13 [0.66, 1.95]
3.1 100 ml 5% NaCl versus 100 ml 10% NaCl combined with PGF 2 230 Odds Ratio (M‐H, Fixed, 95% CI) 0.64 [0.23, 1.78]
3.2 25 ml 20% NaCl versus 100 ml 10% NaCl combined with PGF 2 540 Odds Ratio (M‐H, Fixed, 95% CI) 1.44 [0.74, 2.80]
4 Surgical evacuation 4 770 Odds Ratio (M‐H, Fixed, 95% CI) 1.13 [0.66, 1.95]
4.1 100 ml 5% NaCl versus 100 ml 10% NaCl combined with PGF 2 230 Odds Ratio (M‐H, Fixed, 95% CI) 0.64 [0.23, 1.78]
4.2 25 ml 20% NaCl versus 100 ml 10% NaCl combined with PGF 2 540 Odds Ratio (M‐H, Fixed, 95% CI) 1.44 [0.74, 2.80]
5 Nausea 4 770 Odds Ratio (M‐H, Fixed, 95% CI) 0.58 [0.35, 0.94]
5.1 100 ml 5% NaCl versus 100 ml 10% NaCl combined with PGF 2 230 Odds Ratio (M‐H, Fixed, 95% CI) 1.06 [0.52, 2.19]
5.2 25 ml 20% NaCl versus 100 ml 10% NaCl combined with PGF 2 540 Odds Ratio (M‐H, Fixed, 95% CI) 0.33 [0.17, 0.62]
6 Vomiting 4 770 Odds Ratio (M‐H, Fixed, 95% CI) 0.87 [0.44, 1.72]
6.1 100 ml 5% NaCl versus 100 ml 10% NaCl combined with PGF 2 230 Odds Ratio (M‐H, Fixed, 95% CI) 1.01 [0.33, 3.06]
6.2 25 ml 20% NaCl versus 100 ml 10% NaCl combined with PGF 2 540 Odds Ratio (M‐H, Fixed, 95% CI) 0.79 [0.34, 1.87]
7 Diarrhoea 4 770 Odds Ratio (M‐H, Fixed, 95% CI) 1.09 [0.24, 4.83]
7.1 100 ml 5% NaCl versus 100 ml 10% NaCl combined with PGF 2 230 Odds Ratio (M‐H, Fixed, 95% CI) 0.52 [0.02, 13.13]
7.2 25 ml 20% NaCl versus 100 ml 10% NaCl combined with PGF 2 540 Odds Ratio (M‐H, Fixed, 95% CI) 1.38 [0.23, 8.33]