Bebbington 2002.

Methods	Randomization was performed with a series of sequentially numbered opaque envelopes that contained allocations determined through the use of a random number table.
Participants	114 pregnant women (group I: 49, group II: 65) Inclusion criteria: midtrimester abortion. Exclusion criteria: hypersensitivity to prostaglandins, inability to understand English to ensure informed consent.
Interventions	Group I: misoprostol 400 μg in the posterior vaginal fornix every 4 hours. Group II: misoprostol 200 μg orally every hour for 3 hours and then 400 μg orally every 4 hours. If the patient was undelivered after 24 hours, the attending physician determined further management. The options available were to increase the dosage of misoprostol using the same route of administration, to change the route of administration of the misoprostol, to proceed with a high‐dose oxytocin infusion, or to proceed with surgical evacuation of the uterus.
Outcomes	Primairy outcomes: induction to abortion interval. Secondary outcomes: maternal fever >38°C; maternal infection defined as maternal fever, elevated white blood cell count, and the need for antibiotics in the postabortion period; maternal side effects from the medication including nausea or diarrhoea, blood loss, the need for additional operative intervention; and the failure to achieve a medical termination of pregnancy.
Notes	Definition of abortion: expulsion of the fetus. If the placenta remained undelivered after 2h, an attempt was made at manual extraction under general anaesthesia. No major complications reported.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ adequate
Blinding? All outcomes	High risk
Free of other bias?	Low risk	No statistically significant differences between the groups in terms of maternal age, gestational age and parity.