Herabutya 2005.

Methods	Random allocation by computer generated numbers. The assignments were put into sealed envelopes, which were opened when the women were recruited.
Participants	279 pregnant women (group I: 140, group II: 139) Inclusion criteria: 14‐26 weeks gestation (abortion was not offered > 22 weeks apart from lethal fetal conditions). Exclusion criteria: unstable cardiac disease, recent severe asthmatic attack, severe hepatic or renal impairment, ruptured membranes.
Interventions	All: 600 μg misoprostol vaginally Group I: every 6 hrs, max 9 d; Group II: every 12 hrs, max 5 d.
Outcomes	Primary outcome: induction to abortion interval, abortion within 24 hours. Secondary outcomes: side‐effects.
Notes	Definition of abortion: expulsion of fetus. If the placenta was incomplete or failed to be expelled after 1h, an evacuation of the uterus was carried out under general anaesthesia. No major complications reported.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ adequate
Blinding? All outcomes	High risk
Free of other bias?	Low risk	No statistically significant differences between the groups in terms of maternal age, gestational age and parity.