Ho 1996.
Methods | Randomisation schedule was prepared as described by Meinert. Sealed envelopes with serial numbers on the front and containing the group to which the woman was randomised were opened at recruitment. | |
Participants | 50 pregnant women (group I: 25, group II: 25) Inclusion criteria: 14‐20 weeks gestation. Exclusion criteria: regular use of prescription drugs, IUD in utero, nursing mothers, multiple pregnancies, heavy smokers. |
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Interventions | All: 200mg mifepristone orally (36‐48 hours later): Group I: 400 μg misoprostol orally, every 3 h, max 5 doses; Group II: 1mg gemeprost vaginally, every 6 hours, max 4 doses. The patient was reassessed after 24h. If there were no signs or symptoms suggestive of imminent abortion, the pregnancy was terminated with 1 mg gemeprost every 3 hours. |
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Outcomes | Primary outcome: induction of abortion interval, abortion within 24 hours. Secondary outcomes: side‐effects, uterine contractions, blood pressure, pulse rate. |
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Notes | Definition of abortion: not specified. If the placenta was incomplete, an evacuation of the uterus was carried out. No major complications reported. |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment? | Low risk | A ‐ adequate |
Blinding? All outcomes | High risk | |
Free of other bias? | Low risk | No statistically significant differences between the groups in terms of maternal age, gestational age and gravidity. |