Ho 1997.

Methods	Randomisation schedule as described by Meinert. Schedules were unknown to both patient and clinicans.
Participants	98 pregnant women (group I: 49, group II: 49) Inclusion criteria: good general health, age 16‐35 years, singleton pregnancy, 14‐20 weeks gestation. Exclusion criteria: past or present ill health, nursing mothers, IUD, smoking >10 cigarettes/day.
Interventions	All: mifepristone 200 mg 36‐48 hours later: Group I: misoprostol 200 μg orally, and a placebo vaginally every 3 hours, max 5 doses; Group II: misoprostol 200 μg vaginally, and a placebo orally, every 3 hours, max 5 doses.
Outcomes	Primary outcome: induction of abortion, abortion within 24 hours. Secondary outcomes: side‐effects, uterine contractions, blood pressure, pulse rate.
Notes	Definition of abortion: expulsion of fetus. If the placenta was incomplete or failed to be expelled after 1/2h, an evacuation of the uterus was carried out. No major complications reported.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ adequate
Blinding? All outcomes	Low risk	Blinding of participants and clinicians.
Free of other bias?	Low risk	No statistically significant differences between the groups in terms of maternal age, gestational age and parity.