Kapp 2007.

Methods	Sequentially distributed study number in an allocation ratio of 1:1. The randomisation scheme used permuted blocks of eight, selected by a random number generator created using SAS V.9.3. The pharmacy dispensed the study medication.
Participants	64 pregnant women (group I: 32, group II: 32) Inclusion criteria: 18‐23 weeks of gestation. Exclusion criteria: known allergy to mifepristone/misoprostol/prostaglandins, preexisting intrauterine fetal demise, premature preterm rupture of membranes, IUD in place, history of chronic adrenal failure, porphyrias, concurrent long term corticosteroid treatment.
Interventions	All: intra‐amniotic injection of 1.5 mg digoxin, then: Group I: 200 mg mifepristone, 20–24 hours after study capsule: misoprostol induction using 400 μg misoprostol, followed by 200 μg every 6h (buccally); Group II: 2 placebo tablets (vitamin C). 20–24 hours after study capsule: misoprostol induction using 400 μg misoprostol, followed by 200 μg every 6h (buccally).
Outcomes	Primary outcome: median interval from first misoprostol dose to fetal expulsion. Secondary outcomes: women delivering within 24 hours, proportion of women with a complete delivery requiring additional treatment for retained placenta, the amount of required pain medication, length of hospital stay, side‐effects.
Notes	Definition of abortion: expulsion of fetus. If the placenta was incomplete or failed to be expelled after 4h, an evacuation of the uterus was carried out under general anaesthesia. Heavy bleeding occurred in two women.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ adequate
Blinding? All outcomes	Low risk	Blinding for participants, clinicians, and researchers.
Free of other bias?	Low risk	No statistically significant differences between the groups in terms of maternal age, gestational age and parity.