Nielsen 1975.
Methods | Randomisation. | |
Participants | 32 pregnant women (group I: 16, group II: 16) Inclusion criteria: gestation more than 14 weeks. Exclusion criteria: none reported. |
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Interventions | Group I: suprapublical/transvaginal injection of 20% saline, preceded by removal of 50 mL of amniotic fluid. Amount of saline depending on gestation; 14th week 75 mL, 15th week 100 mL, >16th week 150 mL. Group II: suprapublical/transvaginal injection of 40 mg of PGF2α, preceded by removal of 50 mL of amniotic fluid. Both groups received an 10 IU/h oxytocin drip (100IU in one litre of 5% glucose) within half an hour. If abortion did not occur before 200IU oxytocin was given, the infusion was stopped for 6‐8h and then restarted. PG/saline injection was not repeated. |
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Outcomes | Abortion interval, complications, side‐effects. | |
Notes | Definition of abortion: none given. Curettage was performed in cases which were considered incomplete. No major complications described. |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment? | Low risk | B ‐ unclear |
Blinding? All outcomes | High risk | |
Free of other bias? | Low risk | No apparant differences between the groups in terms of maternal age, gestational age and parity. |