Nuutila 1997 c.

Methods	Randomisation was done using random numbers tables into three groups. A series of numbered, sealed envelopes were prepared containing the allocation.
Participants	53 pregnant women (group I: 27, group II: 26) Inclusion criteria: 12‐24 weeks gestation, singletone pregnancies. Exclusion criteria: none reported.
Interventions	Group I: 100 μg misoprostol vaginally, every 6 hours, max 6 doses. Group II: 200 μg misoprostol vaginally, every 12 hours, max 3 doses.
Outcomes	Primary outcome: induction to abortion interval. Secondary outcomes: side‐effects.
Notes	Definition of abortion: expulsion of fetus and placenta. Within 1h after the passage of the fetus, whether or not the placenta was passed, an evacuation of the uterus was carried out under general anaesthesia. No major complications occurred.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ adequate
Blinding? All outcomes	High risk
Free of other bias?	Low risk	No statistically significant differences between the groups in terms of maternal age, gestational age and parity.