Skip to main content
. 2011 Jan 19;2011(1):CD005216. doi: 10.1002/14651858.CD005216.pub2

Ozerkan 2009.

Methods Randomisation by computer‐generated number lists to two groups of 30.
Participants 60 pregnant women (group I: 30, group II: 30)
Inclusion criteria: 13‐24 weeks gestation.
Exclusion criteria: none reported.
Interventions Group I: 400 μg of misoprostol, vaginally, with an additional 200 μg at two‐hour intervals up to five doses.
Group II: 600 μg of misoprostol, vaginally, with an additional 400μg at four‐hour intervals up to two doses.
Patients in either group received a maximum total dose of 1400g of misoprostol. The next dose was skipped whenever there were effective uterine contractions. If the procedure failed on the first day, it was undertaken the next day using the same protocol. Another method of termination was called in case the procedure failed on two consecutive days.
Outcomes Primary outcome: success rates, time to termination, blood loss, complications, side‐effects and cervical features defined ultrasonographically.
Notes Definition of abortion: expulsion of fetus.
Post‐abortion curettage of the uterine cavity.
No major complications reported.
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Low risk B ‐ unclear
Blinding? 
 All outcomes High risk  
Free of other bias? Low risk No statistically significant differences between the groups in terms of maternal age and gestational age.