Ozerkan 2009.
Methods | Randomisation by computer‐generated number lists to two groups of 30. | |
Participants | 60 pregnant women (group I: 30, group II: 30) Inclusion criteria: 13‐24 weeks gestation. Exclusion criteria: none reported. |
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Interventions | Group I: 400 μg of misoprostol, vaginally, with an additional 200 μg at two‐hour intervals up to five doses. Group II: 600 μg of misoprostol, vaginally, with an additional 400μg at four‐hour intervals up to two doses. Patients in either group received a maximum total dose of 1400g of misoprostol. The next dose was skipped whenever there were effective uterine contractions. If the procedure failed on the first day, it was undertaken the next day using the same protocol. Another method of termination was called in case the procedure failed on two consecutive days. |
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Outcomes | Primary outcome: success rates, time to termination, blood loss, complications, side‐effects and cervical features defined ultrasonographically. | |
Notes | Definition of abortion: expulsion of fetus. Post‐abortion curettage of the uterine cavity. No major complications reported. |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment? | Low risk | B ‐ unclear |
Blinding? All outcomes | High risk | |
Free of other bias? | Low risk | No statistically significant differences between the groups in terms of maternal age and gestational age. |