Su 2005.
Methods | Random allocation; computer‐generated schedule randomisation; numbered, sealed, opaque envelope; envelopes were drawn in consecutive order. | |
Participants | 125 pregnant women (group I: 61, group II: 64) Inclusion criteria: 12‐24 weeks gestation. Exclusion criteria: multiple pregnancies, ≥ 2 previous cesarean sections, missed abortion, oligohydramnios, severe asthma, allergy to prostaglandins. |
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Interventions | Group I: vaginal misoprostol 400 μg /3h, max 5d in 24 hrs. Group II: intra amniotic PGF2α 1,5mg, max 5d in 24 hrs. |
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Outcomes | Primary outcome: induction to abortion interval. Secondary outcomes: abortion within 24 and 48 hours, the need for repeat course of medications, evacuation of uterus, adverse effects. |
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Notes | Definition of abortion: expulsion of the fetus. Evacuation of the uterus was not performed routinely. No major complications reported. |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment? | Low risk | A ‐ adequate |
Blinding? All outcomes | High risk | |
Free of other bias? | Low risk | No statistically significant differences between the groups in terms of maternal age, gestational age and parity. |